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Antibiotic/Steroid
- Antibiotic/Steroid
Prescribing Blephamide®
Indication
ocular surface inflammation with superficial bacterial infection or risk of infection
Mechanism of Action
Sulfacetamide sodium inhibits bacterial folic acid synthesis, crucial for bacterial growth. Prednisolone acetate is a corticosteroid, reducing inflammation by suppressing leukocyte migration and capillary permeability.
Available Quantities
5 ml, 10ml
Dosage/Instructions
Instill 1 drop in affected eye(s) every 4 hours.Safety Info for Blephamide®
Pregnancy & Nursing
Corticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels. The more potent corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. There are no adequate and well-controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids. Therefore, topical corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Pediatric Use
≥6 years
Contraindications, side effects, etc.
Contraindications: Allergy to sulfacetamide sodium, prednisolone, or any part of Blephamide; fungal, TB, or viral infection of the eye. Warnings: Caution if breastfeeding; long-term use may increase risk of cataracts or glaucoma. Side Effects: Common side effects include eye irritation, dizziness. Serious side effects include allergic reactions, changes in eyesight, severe eye irritation, sensitivity to light, rare severe reactions to sulfa drugsulfacetamide 10%, prednisolone acetate 0.2%ophthalmic suspension - Antibiotic/Steroid
Prescribing Blephamide® Ointment
Indication
ocular surface inflammation with superficial bacterial infection or risk of infectionMechanism of Action
Sulfacetamide sodium inhibits bacterial folic acid synthesis, crucial for bacterial growth. Prednisolone acetate is a corticosteroid, reducing inflammation by suppressing leukocyte migration and capillary permeability.Available Quantities
3.5 gm tubeDosage/Instructions
Apply 1/2 inch ribbon to affected eye(s) every 3-4 times per day.Safety Info for Blephamide® Ointment
Pregnancy & Nursing
Corticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels. The more potent corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. There are no adequate and well-controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids. Therefore, topical corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.Pediatric Use
≥6 yearsContraindications, side effects, etc.
Contraindications: Allergy to sulfacetamide sodium, prednisolone, or any part of Blephamide; fungal, TB, or viral infection of the eye. Warnings: Caution if breastfeeding; long-term use may increase risk of cataracts or glaucoma. Side Effects: Common side effects include eye irritation, dizziness. Serious side effects include allergic reactions, changes in eyesight, severe eye irritation, sensitivity to light, rare severe reactions to sulfa drugsulfacetamide 10%, prednisolone acetate 0.2%ophthalmic ointment - Antibiotic/Steroid
Prescribing Cortisporin®
Indication
Treatment of steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where bacterial infection or a risk of bacterial ocular infection existsMechanism of Action
Neomycin inhibits bacterial protein synthesis, Polymyxin B disrupts bacterial cell membrane, Hydrocortisone suppresses the inflammatory response.Available Quantities
7.5mlDosage/Instructions
Instill 1 or 2 drops into the conjunctival sac 2 to 4 times dailySafety Info for Cortisporin®
Pregnancy & Nursing
Corticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels. The more potent corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. There are no adequate and well-controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids. Therefore, topical corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.Pediatric Use
≥2 yearsContraindications, side effects, etc.
Contraindications: Not to be used in viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis, vaccinia, varicella, mycobacterial infection of the eye, fungal diseases of ocular structures, or in individuals with hypersensitivity to any components. Warnings: Not for injection into the eye; prolonged use may result in ocular hypertension/glaucoma, damage to the optic nerve, visual defects, posterior subcapsular cataract formation, and may suppress host response increasing the hazard of secondary ocular infections. Side Effects: Common side effects include eye irritation. Serious side effects include allergic reactions, change in eyesight, very bad eye irritation, conjunctival erythema, itching, swelling, fungal infection of the cornea, viral infection of the cornea, increased intraocular pressure, glaucoma, cataract formation, optic nerve damage, and delayed wound healing.neomycin 0.35%, polymyxin B, hydrocortisone 1%ophthalmic suspension - Antibiotic/Steroid
Prescribing Maxitrol®
Indication
Steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where bacterial infection or a risk of bacterial infection existsMechanism of Action
Neomycin inhibits bacterial protein synthesis, Polymyxin B disrupts bacterial cell membrane, Dexamethasone suppresses the inflammatory responseAvailable Quantities
5 mlDosage/Instructions
Instill 1-2 drops into the conjunctival sac every 4-6 hoursSafety Info for Maxitrol®
Pregnancy & Nursing
Use with caution during pregnancy and nursing.Pediatric Use
≥2 yearsContraindications, side effects, etc.
Contraindications: Not to be used in cases of fungal or viral eye infections, including herpes simplex. Warnings: Use with caution in the presence of glaucoma, recent cataract surgery, eye infections with pus, or a history of cornea or sclera problems. Side Effects: Common include blurred vision and mild eye irritation. Serious side effects include blurred vision, tunnel vision, eye pain, seeing halos around lights, swelling, redness, severe discomfort, crusting or drainage, pain behind the eyes, sudden vision changes, and a wound that will not healneomycin 0.35%, polymyxin B, dexamethasone 0.1%ophthalmic suspension - Antibiotic/Steroid
Prescribing Maxitrol® Ointment
Indication
Steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where bacterial infection or a risk of bacterial infection existsMechanism of Action
Neomycin inhibits bacterial protein synthesis, Polymyxin B disrupts bacterial cell membrane, Dexamethasone suppresses the inflammatory responseAvailable Quantities
3.5 gDosage/Instructions
Apply a 0.5-inch ribbon to the affected eye(s) in the conjunctival sac every 4-6 hoursSafety Info for Maxitrol® Ointment
Pregnancy & Nursing
Use with caution during pregnancy and nursing.Pediatric Use
≥2 yearsContraindications, side effects, etc.
Contraindications: Not to be used in cases of fungal or viral eye infections, including herpes simplex. Warnings: Use with caution in the presence of glaucoma, recent cataract surgery, eye infections with pus, or a history of cornea or sclera problems. Side Effects: Common include blurred vision and mild eye irritation. Serious side effects include blurred vision, tunnel vision, eye pain, seeing halos around lights, swelling, redness, severe discomfort, crusting or drainage, pain behind the eyes, sudden vision changes, and a wound that will not healneomycin 0.35%, polymyxin B, dexamethasone 0.1%ophthalmic ointment - Antibiotic/Steroid
Prescribing Pred-G®
Indication
Steroid-responsive inflammatory conditions with superficial bacterial infection or risk thereofMechanism of Action
Aminoglycosides inhibit bacterial protein synthesis. Corticosteroids inhibit arachidonic acid release, reducing inflammation. Extended use may increase risk of glaucoma and cataractsAvailable Quantities
5 mlDosage/Instructions
Up to 1 drop every hour for the first 24-48 hours, then 1 drop 2-4 times dailySafety Info for Pred-G®
Pregnancy & Nursing
Systemic use during pregnancy can cause fetal hearing loss, limited ophthalmic use is unlikely to cause harm. Fetal harm shown in rats at 500x the ophthalmic human dosePediatric Use
No studiesContraindications, side effects, etc.
Contraindicated in most viral diseases of the cornea and conjunctiva, mycobacterial infection, and fungal diseases of ocular structures. May cause increased intraocular pressure, cataract formation, delayed healing, and secondary ocular infections.Gentamicin sulfate 0.3%, prednisolone acetate 1%ophthalmic solution - Antibiotic/Steroid
Prescribing Pred-G® Ointment
Indication
Ocular surface and palpebral conjunctival inflammation where a risk of bacterial infection existsMechanism of Action
Aminoglycosides inhibit bacterial protein synthesis. Corticosteroids inhibit arachidonic acid release, reducing inflammation. Extended use may increase risk of glaucoma and cataractsAvailable Quantities
3.5gDosage/Instructions
1/2″ ribbon, one to three times dailySafety Info for Pred-G® Ointment
Pregnancy & Nursing
Systemic use of gentamycin can cause fetal hearing loss. Prednisolone is teratogenic in mice at 1-10 times the human ocular dosePediatric Use
No studiesContraindications, side effects, etc.
Contraindicated in most viral diseases of the cornea and conjunctiva, mycobacterial infection, and fungal diseases of ocular structures. May cause increased intraocular pressure, cataract formation, delayed healing, and secondary ocular infections.gentamicin sulfate 0.3%, prednisolone acetate 1%ophthalmic ointment - Antibiotic/Steroid
Prescribing Tobradex ST®
Indication
Indicated for steroid-responsive inflammatory conditions with superficial bacterial infection or risk thereofMechanism of Action
Aminoglycosides inhibit bacterial protein synthesis. Corticosteroids inhibit arachidonic acid release, reducing inflammation. Xanthan gum allows reduction of dexamethasone concentration to 0.05% without reducing efficacy. Extended use may increase risk of glaucoma and cataractsAvailable Quantities
2.5 ml, 5 ml, 10 mlDosage/Instructions
1 or 2 drops every 4-6 hours, every 2 hours for the first 24 or 48 hours if needed, then taperSafety Info for Tobradex ST®
Pregnancy & Nursing
Category C. Ocular administration of dexamethasone is teratogenic in rabbitsPediatric Use
≥2 yearsContraindications, side effects, etc.
Contraindicated in most viral diseases of the cornea and conjunctiva, mycobacterial infection, and fungal diseases of ocular structures. May cause increased intraocular pressure, cataract formation, delayed healing, and secondary ocular infections.Tobramycin 0.3%, Dexamethasone 0.05%ophthalmic suspension - Antibiotic/Steroid
Prescribing Tobradex®
Indication
Indicated for steroid-responsive inflammatory conditions with superficial bacterial infection or risk thereofMechanism of Action
Aminoglycosides inhibit bacterial protein synthesis. Corticosteroids inhibit arachidonic acid release, reducing inflammation. Extended use may increase risk of glaucoma and cataractsAvailable Quantities
2.5 ml, 5 ml, 10 mlDosage/Instructions
1 or 2 drops every 4-6 hours, every 2 hours for the first 24 or 48 hours if needed, then taperSafety Info for Tobradex®
Pregnancy & Nursing
Ocular administration of 0.1% dexamethasone is teratogenic in rabbits. Caution advised in severe or unresponsive keratitis as steroids can exacerbate many nonbacterial infectionsPediatric Use
≥2 years ≥2 years≥2 years≥2 years≥2 years≥2 years≥2 years≥2 years≥2 years≥2 years≥2 yearsContraindications, side effects, etc.
Contraindicated in most viral diseases of the cornea and conjunctiva, mycobacterial infection, and fungal diseases of ocular structures. May cause increased intraocular pressure, cataract formation, delayed healing, and secondary ocular infections.Tobramycin 0.3%, Dexamethasone 0.1%ophthalmic suspension - Antibiotic/Steroid
Prescribing Tobradex® Ointment
Indication
Indicated for steroid-responsive inflammatory conditions with superficial bacterial infection or risk thereofMechanism of Action
Aminoglycosides prevent bacterial protein synthesis. Corticosteroids inhibit arachidonic acid release, reducing inflammation. Extended use may increase risk of glaucoma and cataractsAvailable Quantities
3.5 gm tubeDosage/Instructions
1/2″ ribbonSafety Info for Tobradex® Ointment
Pregnancy & Nursing
Ocular administration of 0.1% dexamethasone has shown teratogenic effects in animal studies. Use with caution in pregnancyPediatric Use
≥2 yearsContraindications, side effects, etc.
Contraindicated in most viral diseases of the cornea and conjunctiva, mycobacterial infection, and fungal diseases of ocular structures. May cause increased intraocular pressure, cataract formation, delayed healing, and secondary ocular infections.Tobramycin 0.3%, Dexamethasone 0.1%ophthalmic ointment - Antibiotic/Steroid
Prescribing Vasocidin®
Indication
Indicated for ocular surface inflammation where superficial bacterial infection or risk thereof existsMechanism of Action
Sulfonamides inhibit bacterial folate synthesis. Corticosteroids inhibit the release of arachidonic acid, reducing inflammationAvailable Quantities
5 mlDosage/Instructions
2 drops every 4 hours, evaluate after 2 days, then taperSafety Info for Vasocidin®
Pregnancy & Nursing
Prednisolone is teratogenic in animals at the normal human ophthalmic dosePediatric Use
≥6 yearsContraindications, side effects, etc.
Contraindicated in most viral diseases of the cornea and conjunctiva, mycobacterial infection, and fungal diseases of ocular structures. May cause increased intraocular pressure, cataract formation, delayed healing, and secondary ocular infections.Sulfacetamide 10%, Prednisolone phosphate (solution) 0.23%ophthalmic solution - Antibiotic/Steroid
Prescribing Zylet®
Indication
Indicated for steroid-responsive inflammatory conditions with superficial bacterial infection or risk thereofMechanism of Action
Aminoglycosides prevent bacterial protein synthesis. Corticosteroids inhibit the release of arachidonic acid, reducing inflammationAvailable Quantities
2.5 ml, 5 ml, 10 mlDosage/Instructions
Instill 1 drop every four to six hours. During the initial 24 to 48 hours, the dosing may be increased, to every one to two hours. Frequency should be decreased gradually as warranted by improvement in clinical signs. Do not to discontinue therapy prematurely.Safety Info for Zylet®
Pregnancy & Nursing
Embryotoxic and teratogenic in animals at 35 times the normal human oral dosePediatric Use
≥6 yearsContraindications, side effects, etc.
Contraindicated in most viral diseases of the cornea and conjunctiva, mycobacterial infection, and fungal diseases of ocular structures. May cause increased intraocular pressure, cataract formation, delayed healing, secondary ocular infections, and exacerbation of viral infections.Tobramycin 0.3%, Loteprednol etabonate 0.5%ophthalmic solution
