Clobetasol propionate is a synthetic corticosteroid that acts as an anti-inflammatory, antipruritic, and vasoconstrictive agent. While the exact mechanism is not fully understood, corticosteroids like clobetasol are thought to work by inducing proteins called lipocortins. These lipocortins inhibit phospholipase A2, an enzyme that releases arachidonic acid from cell membrane phospholipids. By blocking this release, the production of inflammatory mediators like prostaglandins and leukotrienes is reduced, thereby decreasing inflammation, itching, and vasodilation in the affected area.