Acetylcysteine
Indication
Unlabeled use for vernal and giant papillary conjunctivitis, filamentary keratitis, aqueous-deficient dry eye, corneal melt
Mechanism of Action
Intracellular effect on goblet cells during mucin formation softens mucuous, anti-collagenase effect may promote reepitheliazation
Available Quantities
Dosage/Instructions
Dilute to 2% to 5% with artificial tears or saline for use as in aqueous deficient dry eye. Dilute to 10% to 20% and use 4-6x.day for use as an anti-mucolytic or collagenase-inhibiting agent for treatment of ocular burns, filamentary keratopathy, corneal melt, etc.
Pregnancy & Nursing
Limited data; potential risks to the fetus not well established
Pediatric Use
Contraindications, side effects, etc.
Contraindications: Allergy to acetylcysteine.
Warnings/Precautions: Inform medical caregivers if you have a stomach ulcer, stomach bleeding, high blood pressure, congestive heart failure, or kidney disease. Caution advised if you are pregnant or breastfeeding.
Common Side Effects: Mild nausea, stomach upset, vomiting, rash, fever. In rare cases, severe or ongoing vomiting, coughing up blood, and signs of liver damage (such as upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice) may occur.