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Bacitracin Ointment

500 units bacitracin per gram
ophthalmic ointment
Antibiotic
[ cyclic polypeptide antibiotic]
Indication

Indication

bacterial conjunctivitis, bacterial keratitis, bacterial keratoconjunctivitis
Mechanism of Action

Mechanism of Action

Bacitracin forms complexes with divalent metal ions (Mn, Co, Ni, Cu, Zn) that bind to C55-isoprenyl pyrophosphate. This binding inhibits the hydrolysis of lipid dolichol pyrophosphate, ultimately disrupting cell wall synthesis. Additionally, these bacitracin-metal complexes can bind to DNA and induce oxidative cleavage (Susceptible organisms include: Many gram-positive bacteria, including Staphylococcus spp., Streptococcus spp., Corynebacterium spp., Clostridium spp., and Actinomyces spp., and few gram-negative organisms, such as Neisseria spp.— most gram-negative organisms are resistant)
Common quantities available

Available Quantities

3.5 g
Dosage

Dosage/Instructions

Apply directly into the conjunctival sac 1 to 3 times daily. In blepharitis all scales and crusts should be carefully removed and the ointment then spread uniformly over the lid margins.
Pregnancy & Nursing Data

Pregnancy & Nursing

Poorly absorbed after topical application and oral ingestion—considered a low risk to nursing infants and pregnant mothers.
Pediatric Use

Pediatric Use

All ages
Warnings Tab

Contraindications, side effects, etc.

Contraindications: Allergy to bacitracin, zinc, mineral oil, or petroleum jelly. Warnings: Not for use on animal bites, puncture wounds, deep skin wounds, or severe burns. Common Side Effects: Usually has no side effects, but unusual effects should be reported to a doctor.