Byqlovi®
Indication
The treatment of post-operative inflammation and pain following ocular surgery.
Mechanism of Action
Clobetasol propionate is a synthetic corticosteroid that acts as an anti-inflammatory, antipruritic, and vasoconstrictive agent. While the exact mechanism is not fully understood, corticosteroids like clobetasol are thought to work by inducing proteins called lipocortins. These lipocortins inhibit phospholipase A2, an enzyme that releases arachidonic acid from cell membrane phospholipids. By blocking this release, the production of inflammatory mediators like prostaglandins and leukotrienes is reduced, thereby decreasing inflammation, itching, and vasodilation in the affected area.
Available Quantities
Dosage/Instructions
Instill one drop of Clobetasol Propionate Ophthalmic Suspension 0.05% into the affected eye twice daily beginning the day after surgery and continuing throughout the first 2 weeks of the post-operative period.
Pregnancy & Nursing
- No adequate, well-controlled studies in pregnant women
- Animal studies show teratogenic and fetotoxic effects at low systemic doses
- Use during pregnancy only if potential benefit justifies potential fetal risk
- Unknown if present in human milk; potential for growth suppression and interference with endogenous corticosteroid production in breastfed infants
- Consider benefits of breastfeeding along with mother’s clinical need and potential adverse effects on infant
Pediatric Use
Contraindications, side effects, etc.
Contraindicated in active viral eye diseases, mycobacterial eye infections, and ocular fungal diseases. Key warnings include potential for increased intraocular pressure, cataract formation, delayed healing, and corneal/scleral melting. Prolonged use may suppress immune response, increasing risk of secondary infections. It can exacerbate viral infections, especially herpes simplex. Use caution in patients with thinning cornea or sclera