Iopidine®
Apraclonidine 0.5%, (1% singles)
ophthalmic solution
Antiglaucoma
[ Alpha Agonist]
Indication
Short-term adjunctive therapy in patients requiring additional IOP reduction on maximally tolerated medical therapy. Commonly used pre- and post-ocular surgery to control or prevent elevations in IOP.
Mechanism of Action
Apraclonidine is an alpha adrenergic agonist that primarily acts by reducing aqueous humor production and slightly increasing uveoscleral outflow. This action helps lower intraocular pressure.
Available Quantities
5 ml, 10 ml, 0.1 ml singles (2 per pouch)
Dosage/Instructions
1 drop of IOPIDINE* 1% Ophthalmic Solution should be instilled in the scheduled operative eye 1 hour before initiating anterior segment laser surgery and a second drop should be instilled to the same eye immediately upon completion of the laser surgical procedure.
If using for adjunctive glaucoma therapy, 1 drop can be instilled 2 to 3 times daily.
Pregnancy & Nursing
Use with caution during pregnancy and nursing. No adequate and well-controlled studies in pregnant women.
Pediatric Use
Not recommended
Contraindications, side effects, etc.
Contraindications: Iopidine is contraindicated in patients with hypersensitivity to apraclonidine or any other component of the formulation. It should also not be used in patients taking monoamine oxidase inhibitors (MAOIs) due to the potential for a hypertensive crisis. Warnings: Caution is advised in patients with cardiovascular disease, cerebrovascular insufficiency, chronic renal failure, Raynaud’s disease, orthostatic hypotension, or thromboangiitis obliterans. The drug should be used with caution in patients with severe or unstable and uncontrolled cardiovascular disease. Possible Side Effects: Adverse events reported in less than 2% of patients include ocular injection, upper lid elevation, irregular heart rate, nasal decongestion, ocular inflammation, conjunctival blanching, and mydriasis. Other observed adverse events include conjunctival blanching, upper lid elevation, mydriasis, burning, discomfort, foreign body sensation, dryness, itching, hypotony, blurred or dimmed vision, allergic response, conjunctival microhemorrhage, abdominal pain, diarrhea, stomach discomfort, emesis, bradycardia, vasovagal attack, palpitations, orthostatic episode, insomnia, dream disturbances, irritability, decreased libido, taste abnormalities, dry mouth, nasal burning or dryness, headache, chest heaviness or burning, clammy or sweaty palms, body heat sensation, shortness of breath, increased pharyngeal secretion, extremity pain or numbness, fatigue, paresthesia, pruritus not associated with rash, and hypersensitivity