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Lortab®

Hydrocodone and Acetaminophen
oral tablet
Analgesics & Anesthetics
[ Semisynthetic Opioid Agonist (Hydrocodone), Aniline Analgesic (Acetaminophen)]
Indication

Indication

Narcotic for moderate to moderately severe pain relief. Can be used for pain management following ocular procedures like corneal abrasion or iritis
Mechanism of Action

Mechanism of Action

Hydrocodone is a semisynthetic opioid agonist that primarily acts on the mu-opioid receptors in the central nervous system, producing analgesia, respiratory depression, and sedation. Acetaminophen is a non-opioid, non-salicylate analgesic and antipyretic. It works by inhibiting the synthesis of prostaglandins in the central nervous system and peripherally blocking pain impulse generation, producing antipyresis from inhibition of the hypothalamic heat-regulating center
Common quantities available

Available Quantities

5mg, 7.5mg, or 10mg hydrocodone and 325mg or 500 mg acetaminophen
Dosage

Dosage/Instructions

5/325mg: 1 or 2 tabs every 4 to 6 hrs. Do not exceed 12 tablets. 7.5/325mg: 1 tablet every 4 to 6 hrs. Do not exceed 6 tablets. 10/325mg: 1 tablet every 4 to 6 hrs. Do not exceed 6 tablets
Pregnancy & Nursing Data

Pregnancy & Nursing

Use during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated. Caution should be exercised when administered to a nursing woman
Pediatric Use

Pediatric Use

≥18 years
Warnings Tab

Contraindications, side effects, etc.

Contraindications: Avoid use in patients allergic to acetaminophen or hydrocodone, those who have recently used alcohol, sedatives, tranquilizers, other narcotic medications, or MAO inhibitors within the last 14 days. Warnings/Precautions: Be cautious in patients with liver disease, history of alcoholism or drug addiction, bowel issues, low blood pressure, dehydration, head injury, brain tumor, stroke, or respiratory disorders. Older adults and those who are severely ill or malnourished are at increased risk of breathing problems. Use during pregnancy can lead to neonatal withdrawal symptoms. The drug is excreted into breast milk and may harm a nursing baby. Common Side Effects: Include drowsiness, headache, upset stomach, constipation, blurred vision, and dry mouth. More serious effects can include shallow breathing, slow heartbeat, confusion, unusual thoughts or behavior, seizure, easy bruising or bleeding, liver problems, and low cortisol levels.