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Qlosi®

pilocarpine hydrochloride
ophthalmic solution
Aesthetics/Presbyopia
[ Cholinergic Muscarinic Agonist]
Indication

Indication

Treatment of Presbyopia in adults.
Mechanism of Action

Mechanism of Action

Pilocarpine hydrochloride is a cholinergic muscarinic agonist which activates muscarinic receptors located at smooth muscles such as the iris sphincter muscle and ciliary muscle. QLOSI contracts the iris sphincter muscle, constricting the pupil to enhance the depth of focus and improve near visual acuity while maintaining some pupillary response to light.
Common quantities available

Available Quantities

30 pack of 0.4mL single-use vials
Dosage

Dosage/Instructions

Instill one drop of QLOSI in each eye. This can be repeated a second time after 2 to 3 hours for an effect up to 8 hours. QLOSI can be administered on a daily basis, or as needed, up to twice each day.
Pregnancy & Nursing Data

Pregnancy & Nursing

There are no adequate and well-controlled studies of QLOSI administration in pregnant women to inform a drug associated risk. Oral administration of pilocarpine to pregnant rats throughout organogenesis and lactation did not produce adverse effects at clinically relevant doses.
Pediatric Use

Pediatric Use

≥45 years
Warnings Tab

Contraindications, side effects, etc.

Advise patients to not drive or operate machinery if vision is not clear (e.g., blurred vision). Exercise caution in night driving and other hazardous occupations in poor illumination. Rare cases of retinal detachment have been reported with miotics. Examination of the retina is advised in all patients prior to initiation of therapy. Advise patients to seek immediate medical care with sudden onset of flashes of lights, floaters, or vision loss. QLOSI is not recommended to be used when iritis is present. QLOSI should not be administered while wearing contact lenses. Remove lenses prior to the installation of QLOSI and wait 10 minutes before reinsertion. Avoid touching the tip of the vial to the eye or any other surface. Contraindicated in cases of hypersensitivity to any ingredients.