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Restasis®

Cyclosporine 0.05%
ophthalmic emulsion
Dry Eye/OSD
[ Peptide Immunosuppressant]
Indication

Indication

Increase tear production in keratoconjunctivitis sicca due to ocular inflammation
Mechanism of Action

Mechanism of Action

Cyclosporine is a calcineurin inhibitor immunosuppressant. It modulates T-cell function and increases goblet cell density in the conjunctiva, contributing to increased tear production and decreased ocular inflammation in dry eye disease.
Common quantities available

Available Quantities

0.4 ml vials (30 or 60 vials per tray), 5.5 ml in 10 ml bottle
Dosage

Dosage/Instructions

1 drop twice daily, 12 hours apart (Shake emulsion)
Pregnancy & Nursing Data

Pregnancy & Nursing

Category C. Teratogenic in rats at 5000x the human dose. Use cautiously during pregnancy
Pediatric Use

Pediatric Use

≥16 years
Warnings Tab

Contraindications, side effects, etc.

Contraindications: Known hypersensitivity to cyclosporine or any of the ingredients in the formulation. Warnings/Precautions: Not recommended for use in patients with active ocular infections or with a history of herpes viral infections of the eye. Contact lens wearers should remove lenses prior to application and wait 15 minutes before reinsertion. Common Side Effects: Ocular burning, conjunctival hyperemia, discharge, epiphora, eye pain, foreign body sensation, pruritus, stinging, and visual disturbance.