Simbrinza®
Brinzolamide 1%/brimonidine tartrate 0.2%
ophthalmic suspension
Antiglaucoma
[ Carbonic Anhydrase Inhibitor/Alpha-2 Adrenergic Agonist]
Indication
Reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension
Mechanism of Action
Brinzolamide inhibits carbonic anhydrase II in the ciliary processes, which is believed to slow the formation of bicarbonate ions. This reduction leads to decreased sodium and fluid transport, subsequently lowering aqueous humor secretion and reducing intraocular pressure. Brimonidine is a clonidine derivative and a relatively selective α2 adrenergic receptor agonist. It reduces intraocular pressure by decreasing aqueous humor production and increasing uveoscleral outflow. The inhibition of adenylate cyclase leads to reduced cAMP, which modulates aqueous humor dynamics.
Available Quantities
8 mL
Dosage/Instructions
1 drop in the affected eye(s) 3 times daily
Pregnancy & Nursing
Rabbit studies showed maternal toxicity and fetal abnormalities at 120X the normal human dose. There are no adequate and well-controlled studies in pregnant women. Use cautiously during pregnancy.
Pediatric Use
≥2 years
Contraindications, side effects, etc.
Contraindications: Hypersensitivity to any component of this product. Warnings: May cause fatigue and/or drowsiness in some patients. Use with caution in patients with depression, cerebral or coronary insufficiency, Raynaud’s phenomenon, orthostatic hypotension, or thromboangiitis obliterans. Common Side Effects: Eye discomfort/itching/redness/discharge, temporary blurred vision, dry eyes, feeling as if something is in your eye, dry mouth, bitter/sour/unusual taste in mouth.