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Tyrvaya®

0.6 mg/mL (0.06%) varenicline solution
nasal spray
Dry Eye/OSD
[ Selective cholinergic agonist]
Indication

Indication

Treatment of the signs and symptoms of dry eye disease
Mechanism of Action

Mechanism of Action

Tyrvaya activates the trigeminal parasympathetic pathway, resulting in increased tear production. It is a partial nicotinic acetylcholine receptor agonist of α4β2, α4α6β2, α3β4, and α3α5β4 receptors and a full α7 receptor agonist.
Common quantities available

Available Quantities

Carton contains 2 spray bottles – 4.2ml each (60 sprays per bottle)
Dosage

Dosage/Instructions

1 spray in each nostril twice daily
Pregnancy & Nursing Data

Pregnancy & Nursing

At high doses (4864 times the normal dose), rats exhibited reduced body weight. Use cautiously during pregnancy
Pediatric Use

Pediatric Use

No studies
Warnings Tab

Contraindications, side effects, etc.

Contraindications: Allergic reactions to varenicline or other ingredients in the formulation. Warnings/Precautions: Patients should inform their healthcare provider if they are pregnant, planning a pregnancy, or breastfeeding. The medication is for nasal use only. Common Side Effects: Sneezing, cough, throat irritation, nose irritation. Most side effects are mild, and less than 2% of patients in clinical trials discontinued treatment due to side effects.