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Vibramycin®

doxycycline
intravenous infusion, oral capsule, oral suspension
Antibiotic
[ Tetracycline Antibiotic]
Indication

Indication

Treatment of ocular infections such as inclusion conjunctivitis, trachoma, meibomian gland dysfunction (MGD), ocular rosacea, and recurrent corneal erosion
Mechanism of Action

Mechanism of Action

Inhibits protein synthesis, binding to the 30s ribosomal subunit of the mRNA. Inhibits production of metalloproteinases and other cytokines. May inhibit production of bacterial lipases.
Common quantities available

Available Quantities

20 mg tablets, 100 mg tablets and capsules
Dosage

Dosage/Instructions

Meibomian gland disease: 20mg – 50mg BID for 4 weeks then QD for another 4 to 8 weeks. Adult Inclusion Conjunctivitis: 100mg BID X 7 days. Recurrent Corneal Erosion: 50 to 100mg BID for 8 to 12 wks.
Pregnancy & Nursing Data

Pregnancy & Nursing

Tetracyclines can cause changes in both deciduous and permanent teeth during the time of tooth development; these changes include dysgenesis, staining, and an increased tendency to caries. Discoloration may be progressive and can vary from yellowish brown to dark gray. Because of bone growth depression and tooth discoloration, women in the last half of pregnancy, nursing mothers, and children under 8 years of age should avoid tetracyclines.
Pediatric Use

Pediatric Use

≥8 years
Warnings Tab

Contraindications, side effects, etc.

Contraindications: Hypersensitivity to doxycycline or other tetracyclines. Warnings/Precautions: Avoid in children under 8 years old due to the risk of tooth discoloration. Use caution in patients with hepatic impairment or those taking hepatotoxic drugs. Photosensitivity is possible. Common Side Effects: Gastrointestinal discomfort (nausea, vomiting, diarrhea), photosensitivity, rash, and rarely, esophageal ulceration and Clostridium difficile-associated diarrhea.