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aberrant regeneration

Aberrant regeneration is a possible sequela of an oculomotor nerve palsy, resulting in abnormal lid, pupillary, and ocular motility. It occurs when regenerating axons are misdirected to anomalous connections within the oculomotor nerve. Common signs include lid elevation on adduction (pseudo-Graefe’s sign) or infraduction, and pupillary constriction on adduction. The most frequent causes are trauma, tumors, and aneurysms. Onset typically appears within 6-12 months after the initial injury.

 

(Rutstein, 11/1997, p. 347)

Rutstein, R., Daum, K. 1997, Anomalies of Binocular Vision: Diagnosis & Management, Mosby. Available from: vbk://978-0-8016-6916-3

Carrasco, J.R., Savino, P.J. and Bilyk, J.R. (2002) ‘Primary Aberrant Oculomotor Nerve Regeneration From a Posterior Communicating Artery Aneurysm’, Archives of Ophthalmology, 120(5), pp. 663–665.

EyeWiki (2023) Oculomotor Synkinesis. Available at: https://eyewiki.aao.org/Oculomotor_Synkinesis (Accessed: 4 May 2024).

Giffin, N.J. and Goadsby, P.J. (2007) ‘Aberrant regeneration of the oculomotor nerve: implications for neurosurgeons’, Neurosurgical Focus, 23(5), p. E14.

Sibony, P.A., Lessell, S. and Gittinger, J.W. (1984) ‘Acquired oculomotor synkinesis’, Survey of Ophthalmology, 28(5), pp. 382–390.